PD-L1/PD-1 crosstalk in colorectal cancer: are we targeting the right cells?

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/35293

Title:	PD-L1/PD-1 crosstalk in colorectal cancer: are we targeting the right cells?
Authors:	Cantero-Cid, Ramón Casas-Martin, José Hernández-Jiménez, Enrique Cubillos-Zapata, Carolina Varela-Serrano, Aníbal Avendaño-Ortiz, José Casarrubios, Marta Montalbán-Hernández, Karla Villacañas-Gil, Ignacio Guerra-Pastrián, Laura Peinado, Begoña Marcano, Cristóbal Aguirre, Luis A López-Collazo, Eduardo View more
Keywords:	Colorectal cancer Immune checkpoints MMR status PD-L1/PD-1 T-cell exhaustion View more
Mesh:	Aged Aged, 80 and over B7-H1 Antigen Cell Line, Tumor Colorectal Neoplasms Female Humans Lymphocyte Activation Lymphocytes, Tumor-Infiltrating Male Microsatellite Instability Middle Aged Neoplasm Metastasis Neoplasm Staging Neoplastic Stem Cells Phenotype Programmed Cell Death 1 Receptor Protein Binding T-Lymphocyte Subsets Biomarkers, Tumor Signal Transduction View more
Issue Date:	3-Oct-2018
Citation:	BMC Cancer.2018 Oct;(18)1:945
Abstract:	The analysis of tumour-infiltrating immune cells within patients' tumour samples in colorectal cancer (CRC) has become an independent predictor of patient survival. The tumour microenvironment and the immune checkpoints, such as PD-L1/PD-1, are relevant to the prognoses and also appear to be relevant for further CRC therapies.
PMID:	30285662
URI:	https://hdl.handle.net/20.500.12530/35293
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos Hospitales > H. U. La Paz > Artículos

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