Primary constitutional MLH1 epimutations: a focal epigenetic event.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/35309

Title:	Primary constitutional MLH1 epimutations: a focal epigenetic event.
Authors:	Dámaso, Estela Castillejo, Adela Arias, María Del Mar Canet-Hermida, Julia Navarro, Matilde Del Valle, Jesús Campos, Olga Fernández, Anna Marín, Fátima Turchetti, Daniela García-Díaz, Juan de Dios Lázaro, Conxi Genuardi, Maurizio Rueda, Daniel Alonso, Ángel Soto, Jose Luis Hitchins, Megan Pineda, Marta Capellá, Gabriel View more
Issue Date:	Oct-2018
Citation:	Br. J. Cancer.2018 Oct;(119)8:978-987
Abstract:	Constitutional MLH1 epimutations are characterised by monoallelic methylation of the MLH1 promoter throughout normal tissues, accompanied by allele-specific silencing. The mechanism underlying primary MLH1 epimutations is currently unknown. The aim of this study was to perform an in-depth characterisation of constitutional MLH1 epimutations targeting the aberrantly methylated region around MLH1 and other genomic loci.
PMID:	30283143
URI:	https://hdl.handle.net/20.500.12530/35309
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos Fundaciones e Institutos de Investigación > FIB H. U. Príncipe de Asturias > Artículos

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