Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/35842
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dc.contributor.authorEnamorado, Michel
dc.contributor.authorKhouili, Sofía C
dc.contributor.authorIborra, Salvador
dc.contributor.authorSancho, David
dc.date.accessioned2019-06-28T18:01:32Z-
dc.date.available2019-06-28T18:01:32Z-
dc.date.issued2018
dc.identifier.citationFront Immunol.2018;(9):1751
dc.identifier.urihttps://hdl.handle.net/20.500.12530/35842-
dc.description.abstractTissue-resident memory CD8+ T (Trm) cells define a distinct non-recirculating subset. Trm cells constitute a first line of defense against local infections in barrier tissues, but they are also found in non-barrier tissues and play a role in antitumor immunity. Their differentiation in tissues and their phenotypical, transcriptional, and functional characteristics are the object of active research. Herein, we will discuss the potential existence of committed CD8+ Trm precursors and the genealogy of memory CD8+ T cell subsets. In addition to the priming of naive T cells, there is some plasticity of antigen-experienced effector and memory T cell subsets to generate Trm precursors. Local inflammation, antigen presentation, and cytokines drive Trm differentiation. It is of prime interest how specific dendritic cell subsets modulate priming and differentiation of Trm cells, as well as their reactivation within tissues. Research on how we can manipulate generation of memory T cells subsets is key for improved vaccination strategies.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectcirculating memory
dc.subjectdendritic cells
dc.subjectdifferentiation
dc.subjectinfection
dc.subjectmemory CD8+ T cell
dc.subjectplasticity
dc.subjectpriming
dc.subjecttissue-resident memory
dc.titleGenealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells.
dc.typeArtículo
dc.identifier.pubmedID30108585
dc.format.volume9
dc.format.page1751
dc.identifier.e-issn1664-3224
dc.identifier.journalFrontiers in immunology
dc.identifier.doi10.3389/fimmu.2018.01751
dc.identifier.pmcPMC6079237
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos

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