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Title: Sailing to and Docking at the Immune Synapse: Role of Tubulin Dynamics and Molecular Motors.
Authors: Martín-Cófreces, Noa Beatriz
Sánchez-Madrid, Francisco
Issue Date: 2018
Citation: Front Immunol.2018;(9):1174
Abstract: The different cytoskeleton systems and their connecting molecular motors move vesicles and intracellular organelles to shape cells. Polarized cells with specialized functions display an exquisite spatio-temporal regulation of both cytoskeletal and organelle arrangements that support their specific tasks. In particular, T cells rapidly change their shape and cellular function through the establishment of cell surface and intracellular polarity in response to a variety of cues. This review focuses on the contribution of the microtubule-based dynein/dynactin motor complex, the tubulin and actin cytoskeletons, and different organelles to the formation of the antigen-driven immune synapse.
PMID: 29910809
Rights: openAccess
ISSN: 1664-3224
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos

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