Co-crystal of Tramadol-Celecoxib in Patients with Moderate to Severe Acute Post-surgical Oral Pain: A Dose-Finding, Randomised, Double-Blind, Placebo- and Active-Controlled, Multicentre, Phase II Trial.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/36626

Title:	Co-crystal of Tramadol-Celecoxib in Patients with Moderate to Severe Acute Post-surgical Oral Pain: A Dose-Finding, Randomised, Double-Blind, Placebo- and Active-Controlled, Multicentre, Phase II Trial.
Authors:	López-Cedrún, José Videla, Sebastián Burgueño, Miguel Juárez, Inma Aboul-Hosn, Samir Martín-Granizo, Rafael Grau, Joan Puche, Miguel Gil-Diez, José-Luis Hueto, José-Antonio Vaqué, Anna Sust, Mariano Plata-Salamán, Carlos Monner, Antoni View more
Mesh:	Adult Analgesics, Opioid Celecoxib Cyclooxygenase 2 Inhibitors Dose-Response Relationship, Drug Double-Blind Method Drug Combinations Female Humans Male Pain, Postoperative Tramadol Young Adult View more
Issue Date:	Jun-2018
Citation:	Drugs R D.2018 Jun;(18)2:137-148
Abstract:	Co-crystal of tramadol-celecoxib (CTC), containing equimolar quantities of the active pharmaceutical ingredients (APIs) tramadol and celecoxib (100 mg CTC = 44 mg rac-tramadol hydrochloride and 56 mg celecoxib), is a novel API-API co-crystal for the treatment of pain. We aimed to establish the effective dose of CTC for treating acute pain following oral surgery.
PMID:	29799099
URI:	https://hdl.handle.net/20.500.12530/36626
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos Hospitales > H. U. La Paz > Artículos

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