Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/36633
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dc.contributor.authorGutierrez-Camino, Angela
dc.contributor.authorMartin-Guerrero, Idoia
dc.contributor.authorDolzan, Vita
dc.contributor.authorJazbec, Janez
dc.contributor.authorCarbone-Bañeres, Ana
dc.contributor.authorGarcia de Andoin, Nagore
dc.contributor.authorSastre, Ana
dc.contributor.authorAstigarraga, Itziar
dc.contributor.authorNavajas, Aurora
dc.contributor.authorGarcia-Orad, Africa
dc.date.accessioned2019-06-28T18:16:55Z-
dc.date.available2019-06-28T18:16:55Z-
dc.date.issued2018-05-01
dc.identifier.citationOncotarget.2018 May;(9)33:22907-22914
dc.identifier.urihttps://hdl.handle.net/20.500.12530/36633-
dc.description.abstractAcute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that regulate more than 50% of genes, including those involved in B-cell maturation, differentiation and proliferation. Genetic variants in miRNAs can alter their own levels or function, affecting their target gene expression, and then, may affect ALL risk. Therefore, the aim of this study was to determine the role of miRNA genetic variants in B-ALL susceptibility. We analyzed all variants in pre-miRNAs (MAF > 1%) in two independent cohorts from Spain and Slovenia and inferred their functional effect by in silico analysis. SNPs rs12402181 in miR-3117 and rs62571442 in miR-3689d2 were associated with ALL risk in both cohorts, possibly through their effect on MAPK signalling pathway. These SNPs could be novel markers for ALL susceptibility.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectMAPK signalling pathway
dc.subjectSNP
dc.subjectacute lymphoblastic leukemia
dc.subjectmiRNAs
dc.subjectsusceptibility
dc.titleInvolvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk.
dc.typeArtículo
dc.identifier.pubmedID29796161
dc.format.volume9
dc.format.page22907-22914
dc.identifier.e-issn1949-2553
dc.identifier.journalOncotarget
dc.identifier.doi10.18632/oncotarget.25144
dc.format.number33
dc.identifier.pmcPMC5955428
dc.pubmedtypeJournal Article
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos
Hospitales > H. U. La Paz > Artículos

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