Population pharmacokinetics/pharmacodynamics of micafungin against Candida species in obese, critically ill, and morbidly obese critically ill patients.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/37072

Title:	Population pharmacokinetics/pharmacodynamics of micafungin against Candida species in obese, critically ill, and morbidly obese critically ill patients.
Authors:	Maseda, Emilio Grau, Santiago Luque, Sonia Castillo-Mafla, Maria-Pilar Suárez-de-la-Rica, Alejandro Montero-Feijoo, Ana Salgado, Patricia Gimenez, Maria-Jose García-Bernedo, Carlos A Gilsanz, Fernando Roberts, Jason A View more
Keywords:	Candida spp. Intensive care unit Monte-Carlo simulation Morbid obesity PK/PD View more
Mesh:	Adult Aged Aged, 80 and over Antifungal Agents Area Under Curve Body Mass Index Candidiasis Critical Illness Echinocandins Female Humans Lipopeptides Male Micafungin Microbial Sensitivity Tests Middle Aged Monte Carlo Method Obesity Obesity, Morbid ROC Curve Spain Dose-Response Relationship, Drug View more
Issue Date:	15-Apr-2018
Citation:	Crit Care.2018 Apr;(22)1:94
Abstract:	Dosing in obese critically ill patients is challenging due to pathophysiological changes derived from obesity and/or critical illness, and it remains fully unexplored. This study estimated the micafungin probability of reaching adequate 24-h area under the curve (AUC0-24h)/minimum inhibitory concentration (MIC) values against Candida spp. for an obese/nonobese, critically ill/noncritically ill, large population.
PMID:	29655372
URI:	https://hdl.handle.net/20.500.12530/37072
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos Hospitales > H. U. La Paz > Artículos

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