JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.

Sanchez, Gina A Montealegre; Reinhardt, Adam; Ramsey, Suzanne; Wittkowski, Helmut; Hashkes, Philip J; Berkun, Yackov; Schalm, Susanne; Murias, Sara; Dare, Jason A; Brown, Diane; Stone, Deborah L; Gao, Ling; Klausmeier, Thomas; Foell, Dirk; de Jesus, Adriana A; Chapelle, Dawn C; Kim, Hanna; Dill, Samantha; Colbert, Robert A; Failla, Laura; Kost, Bahar; O'Brien, Michelle; Reynolds, James C; Folio, Les R; Calvo, Katherine R; Paul, Scott M; Weir, Nargues; Brofferio, Alessandra; Soldatos, Ariane; Biancotto, Angelique; Cowen, Edward W; Digiovanna, John J; Gadina, Massimo; Lipton, Andrew J; Hadigan, Colleen; Holland, Steven M; Fontana, Joseph; Alawad, Ahmad S; Brown, Rebecca J; Rother, Kristina I; Heller, Theo; Brooks, Kristina M; Kumar, Parag; Brooks, Stephen R; Waldman, Meryl; Singh, Harsharan K; Nickeleit, Volker; Silk, Maria; Prakash, Apurva; Janes, Jonathan M; Ozen, Seza; Wakim, Paul G; Brogan, Paul A; Macias, William L; Goldbach-Mansky, Raphaela

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/37096

Title:	JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.
Authors:	Sanchez, Gina A Montealegre Reinhardt, Adam Ramsey, Suzanne Wittkowski, Helmut Hashkes, Philip J Berkun, Yackov Schalm, Susanne Murias, Sara Dare, Jason A Brown, Diane Stone, Deborah L Gao, Ling Klausmeier, Thomas Foell, Dirk de Jesus, Adriana A Chapelle, Dawn C Kim, Hanna Dill, Samantha Colbert, Robert A Failla, Laura Kost, Bahar O'Brien, Michelle Reynolds, James C Folio, Les R Calvo, Katherine R Paul, Scott M Weir, Nargues Brofferio, Alessandra Soldatos, Ariane Biancotto, Angelique Cowen, Edward W Digiovanna, John J Gadina, Massimo Lipton, Andrew J Hadigan, Colleen Holland, Steven M Fontana, Joseph Alawad, Ahmad S Brown, Rebecca J Rother, Kristina I Heller, Theo Brooks, Kristina M Kumar, Parag Brooks, Stephen R Waldman, Meryl Singh, Harsharan K Nickeleit, Volker Silk, Maria Prakash, Apurva Janes, Jonathan M Ozen, Seza Wakim, Paul G Brogan, Paul A Macias, William L Goldbach-Mansky, Raphaela View more
Keywords:	Immunology Innate immunity Monogenic diseases Therapeutics Translation View more
Issue Date:	2-Jul-2018
Citation:	J. Clin. Invest..2018 Jul;(128)7:3041-3052
Abstract:	Monogenic IFN-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN response gene signature, inflammatory organ damage, and high mortality. We used the JAK inhibitor baricitinib, with IFN-blocking activity in vitro, to ameliorate disease.
PMID:	29649002
URI:	https://hdl.handle.net/20.500.12530/37096
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos Hospitales > H. U. La Paz > Artículos

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