Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.12530/37202
Title: | Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment. | |
Authors: | ||
Keywords: | ||
Issue Date: | 3-Apr-2018 | |
Citation: | Diseases.2018 Apr;(6)2: | |
Abstract: | Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over controlled clinical trial was carried out in 45 people (25 women). Commercial milk, containing 2.24 g of sterols, was ingested daily during a 3-week period, and then the same amount of skim milk, without sterols, was consumed daily during the 3-week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Genes LIPC C-514T and APOA5 C56G are Ser19Trp carriers and greatly benefit from sterol intake in the diet. LIPC C-514T TT homozygous carriers had lower low-density lipoprotein cholesterol (LDL-c) levels than CC homozygote and CT heterozygote carriers after the ingestion of plant sterols (p = 0.001). These two genes also showed statistically significant changes in total cholesterol levels (p = 0.025; p = 0.005), and no significant changes in high-density lipoprotein (HDL) cholesterol levels (p = 0.032; p = 0.003), respectively. No statistically significant differences were observed for other genes. Further studies are needed to establish which genotype combinations would be the most protective against hypercholesterolemia. | |
PMID: | 29614023 | |
URI: | https://hdl.handle.net/20.500.12530/37202 | |
Rights: | openAccess | |
ISSN: | 2079-9721 | |
Appears in Collections: | Hospitales > H. El Escorial > Artículos | |
Files in This Item:
File | Description | Size | Format | |
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PMC6023396.pdf | 8.3 MB | Adobe PDF | View/Open |
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