Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/37525
Title: Huge recurrent gastric neuroendocrine tumor: a second-line chemotherapeutic dilemma.
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Issue Date: Jan-2018
Citation: Autops Case Rep.;(8)1:e2018005
Abstract: Chemotherapy is considered "state of the art" for the treatment of poorly differentiated neuroendocrine neoplasms. Unfortunately, there is no standard effective post-first-line treatment for relapsing high-grade gastroenteropancreatic neuroendocrine neoplasms. We report the case of a patient with a gastric neuroendocrine carcinoma stage IV, with massive gastrointestinal bleeding at diagnosis. After the first line of platin-based chemotherapy a major tumoral response was documented, but the patient relapsed after 4 months. A second line of chemotherapy treatment was given, with the FOLFOX regimen, and the patient has been free of progression for almost 2 years. There is no second-line standard treatment accepted for this type of carcinoma, but 5-fluorouracil combined with oxaliplatin showed interesting antitumor activity.
PMID: 29515980
URI: https://hdl.handle.net/20.500.12530/37525
Rights: openAccess
ISSN: 2236-1960
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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