Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/37720

Title:	Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.
Authors:	Bartolome, Fernando de la Cueva, Macarena Pascual, Consuelo Antequera, Desiree Fernandez, Tamara Gil, Carmen Martinez, Ana Carro, Eva View more
Keywords:	Alzheimer’s disease Hippocampus Memory Mitochondria Mitophagy Neurogenesis Oral administration Phosphodiesterase Transgenic mice View more
Issue Date:	2018
Citation:	Alzheimers Res Ther.2018 02;(10)1:24
Abstract:	The phosphodiesterase (PDE) 7 inhibitor S14 is a cell-permeable small heterocyclic molecule that is able to cross the blood-brain barrier. We previously found that intraperitoneal treatment with S14 exerted neuroprotection in an Alzheimer's disease (AD) model (in APP/PS1 mice). The objective of this study was to investigate the neurogenic and cellular effects of oral administration of S14 on amyloid β (Aβ) overload.
PMID:	29458418
URI:	https://hdl.handle.net/20.500.12530/37720
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos

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