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dc.contributor.authorDierssen-Sotos, Trinidad
dc.contributor.authorGómez-Acebo, Inés
dc.contributor.authorPalazuelos, Camilo
dc.contributor.authorFernández-Navarro, Pablo
dc.contributor.authorAltzibar, Jone M
dc.contributor.authorGonzález-Donquiles, Carmen
dc.contributor.authorArdanaz, Eva
dc.contributor.authorBustamante, Mariona
dc.contributor.authorAlonso-Molero, Jéssica
dc.contributor.authorVidal, Carmen
dc.contributor.authorBayo-Calero, Juan
dc.contributor.authorTardón, Adonina
dc.contributor.authorSalas, Dolores
dc.contributor.authorMarcos-Gragera, Rafael
dc.contributor.authorMoreno, Víctor
dc.contributor.authorRodriguez-Cundin, Paz
dc.contributor.authorVinyals, Gemma Castaño
dc.contributor.authorEderra, María
dc.contributor.authorVilorio-Marqués, Laura
dc.contributor.authorAmiano, Pilar
dc.contributor.authorPérez-Gómez, Beatriz
dc.contributor.authorAragonés, Nuria
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorPollán, Marina
dc.contributor.authorLlorca, Javier
dc.identifier.citationSci Rep.2018 Feb;(8)1:3036
dc.description.abstractA breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI = 0.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.
dc.titleValidating a breast cancer score in Spanish women. The MCC-Spain study.
dc.identifier.journalScientific reports
dc.pubmedtypeJournal Article
Appears in Collections:Hospitales > H. U. Puerta de Hierro Majadahonda > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Puerta de Hierro-Segovia de Arana > Artículos

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