Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/37814
Title: Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism.
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Issue Date: 2018
Citation: Ann. Rheum. Dis..2018 05;(77)5:752-759
Abstract: Methotrexate (MTX) is the anchor drug for treatment of rheumatoid arthritis (RA), but the mechanism of its anti-inflammatory action is not fully understood. In RA, macrophages display a proinflammatory polarisation profile that resembles granulocyte-macrophage colony-stimulating factor (GM-CSF)-differentiated macrophages and the response to MTX is only observed in thymidylate synthase+ GM-CSF-dependent macrophages. To determine the molecular basis for the MTX anti-inflammatory action, we explored toll-like receptor (TLR), RA synovial fluid (RASF) and tumour necrosis factor receptor (TNFR)-initiated signalling in MTX-exposed GM-CSF-primed macrophages.
PMID: 29431121
URI: https://hdl.handle.net/20.500.12530/37814
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos

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