The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib.

Vishwanathan, Karthick; Dickinson, Paul A; So, Karen; Thomas, Karen; Chen, Yuh-Min; De Castro Carpeño, Javier; Dingemans, Anne-Marie C; Kim, Hye Ryun; Kim, Joo-Hang; Krebs, Matthew G; Chih-Hsin Yang, James; Bui, Khanh; Weilert, Doris; Harvey, R Donald

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/37982

Title:	The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib.
Authors:	Vishwanathan, Karthick Dickinson, Paul A So, Karen Thomas, Karen Chen, Yuh-Min De Castro Carpeño, Javier Dingemans, Anne-Marie C Kim, Hye Ryun Kim, Joo-Hang Krebs, Matthew G Chih-Hsin Yang, James Bui, Khanh Weilert, Doris Harvey, R Donald View more
Keywords:	clinical pharmacology, drug metabolism drug analysis, lung cancer drug information drug interactions oncology pharmacokinetics, biomarkers View more
Mesh:	Administration, Oral Adult Aged Aged, 80 and over Antineoplastic Agents Carcinoma, Non-Small-Cell Lung Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Drug Administration Schedule Drug Interactions Female Humans Itraconazole Lung Neoplasms Male Middle Aged Models, Biological Piperazines Protein Kinase Inhibitors Rifampin Risk Assessment Risk Factors Treatment Outcome View more
Issue Date:	2018
Citation:	Br J Clin Pharmacol.2018 06;(84)6:1156-1169
Abstract:	We investigated the effects of a strong CYP3A4 inhibitor (itraconazole) or inducer (rifampicin) on the pharmacokinetics of the epidermal growth factor receptor-tyrosine kinase inhibitor osimertinib, in patients with advanced non-small cell lung cancer in two Phase I, open-label, two-part clinical studies. Part one of both studies is reported.
PMID:	29381826
URI:	https://hdl.handle.net/20.500.12530/37982
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos Hospitales > H. U. La Paz > Artículos

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