Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/38040
Title: Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching.
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Issue Date: 2018
Citation: PLoS ONE.2018;(13)1:e0191239
Abstract: Current treatment with vasodilators for pulmonary hypertension associated with respiratory diseases is limited by their inhibitory effect on hypoxic pulmonary vasoconstriction (HPV) and uncoupling effects on ventilation-perfusion (V'/Q'). Hypoxia is also a well-known modulator of the nitric oxide (NO) pathway, and may therefore differentially affect the responses to phosphodiesterase 5 (PDE5) inhibitors and soluble guanylyl cyclase (sGC) stimulators. So far, the effects of the sGC stimulator riociguat on HPV have been poorly characterized.
PMID: 29364918
URI: https://hdl.handle.net/20.500.12530/38040
Rights: openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos

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