Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.12530/38040| Title: | Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching. | |
| Authors: | ||
| Mesh: | ||
| Issue Date: | 2018 | |
| Citation: | PLoS ONE.2018;(13)1:e0191239 | |
| Abstract: | Current treatment with vasodilators for pulmonary hypertension associated with respiratory diseases is limited by their inhibitory effect on hypoxic pulmonary vasoconstriction (HPV) and uncoupling effects on ventilation-perfusion (V'/Q'). Hypoxia is also a well-known modulator of the nitric oxide (NO) pathway, and may therefore differentially affect the responses to phosphodiesterase 5 (PDE5) inhibitors and soluble guanylyl cyclase (sGC) stimulators. So far, the effects of the sGC stimulator riociguat on HPV have been poorly characterized. | |
| PMID: | 29364918 | |
| URI: | https://hdl.handle.net/20.500.12530/38040 | |
| Rights: | openAccess | |
| Appears in Collections: | Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| PMC5783366.pdf | 2.87 MB | Adobe PDF |  View/Open |
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