Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/38440
Title: Sequencing of FKS Hot Spot 1 from Saprochaete capitata To Search for a Relationship to Reduced Echinocandin Susceptibility.
Authors: 
Keywords: antifungal resistance
Mesh: 
Issue Date: 2018
Citation: Antimicrob. Agents Chemother..2018 02;(62)2:
Abstract: Saprochaete capitata, formerly known as Geotrichum capitatum, is an emerging fungal pathogen with low susceptibility to echinocandins. Here, we report the nucleotide sequence of the S. capitata hot spot 1 region of the FKS gene (FKS HS1), which codifies for the catalytic subunit of β-1,3-d-glucan synthase, the target of echinocandins. For that purpose, we first designed degenerated oligonucleotide primers derived from conserved flanking regions of the FKS1 HS1 segment of 12 different fungal species. Interestingly, analysis of the translated FKS HS1 sequences of 12 isolates of S. capitata revealed that all of them exhibited the same F-to-L substitution in a position that is highly related to reduced echinocandin susceptibility.
PMID: 29229638
URI: https://hdl.handle.net/20.500.12530/38440
Rights: openAccess
Appears in Collections:Hospitales > H. U. Severo Ochoa > Artículos

Files in This Item:
File Description SizeFormat 
PMC5786795.pdf1.4 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.