Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/38691

Title:	Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis.
Authors:	González-Rodríguez, Águeda Valdecantos, M Pilar Rada, Patricia Addante, Annalisa Barahona, Inés Rey, Esther Pardo, Virginia Ruiz, Laura Laiglesia, Laura M Moreno-Aliaga, María J García-Monzón, Carmelo Sánchez, Aránzazu Valverde, Ángela M View more
Keywords:	Inflammation Oval cells PTP1B Steatohepatitis Steatosis View more
Mesh:	Animals Cells, Cultured Choline Diet Epithelial Cell Adhesion Molecule Fibroblast Growth Factors Humans Interleukin-1beta Interleukin-6 Keratin-19 Liver Macrophages Male Methionine Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease Protein Tyrosine Phosphatase, Non-Receptor Type 1 View more
Issue Date:	2018
Citation:	Mol Metab.2018 01;(7):132-146
Abstract:	Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. Protein tyrosine phosphatase 1B (PTP1B), a negative modulator of insulin and cytokine signaling, is a therapeutic target for type 2 diabetes and obesity. We investigated the impact of PTP1B deficiency during NAFLD, particularly in non-alcoholic steatohepatitis (NASH).
PMID:	29126873
URI:	https://hdl.handle.net/20.500.12530/38691
Rights:	openAccess
Appears in Collections:	Hospitales > H. U. Santa Cristina > Artículos Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

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