Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/39764
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dc.contributor.authorOssorio, Marta
dc.contributor.authorBajo, María Auxiliadora
dc.contributor.authorDel Peso, Gloria
dc.contributor.authorMartínez, Virginia
dc.contributor.authorFernández, María
dc.contributor.authorCastro, María José
dc.contributor.authorRodríguez-Sanz, Aranzazu
dc.contributor.authorMadero, Rosario
dc.contributor.authorBellón, Teresa
dc.contributor.authorSelgas, Rafael
dc.date.accessioned2019-07-01T06:23:20Z-
dc.date.available2019-07-01T06:23:20Z-
dc.date.issued2017
dc.identifier.citationPLoS ONE.2017;(12)4:e0175835
dc.identifier.urihttps://hdl.handle.net/20.500.12530/39764-
dc.description.abstractPeritoneal membrane failure (PMF) and, ultimately, encapsulating peritoneal sclerosis (EPS) are the most serious peritoneal dialysis (PD) complications. Combining clinical and peritoneal transport data with the measurement of molecular biomarkers, such as the chemokine CCL18, would improve the complex diagnosis and management of PMF. We measured CCL18 levels in 43 patients' effluent and serum at baseline and after 1, 2, and 3 years of PD treatment by retrospective longitudinal study, and evaluated their association with PMF/EPS development and peritoneal risk factors. To confirm the trends observed in the longitudinal study, a cross-sectional study was performed on 61 isolated samples from long-term (more than 3 years) patients treated with PD. We observed that the patients with no membrane dysfunction showed sustained low CCL18 levels in peritoneal effluent over time. An increase in CCL18 levels at any time was predictive of PMF development (final CCL18 increase over baseline, p = .014; and maximum CCL18 increase, p = .039). At year 3 of PD, CCL18 values in effluent under 3.15 ng/ml showed an 89.5% negative predictive value, and higher levels were associated with later PMF (odds ratio 4.3; 95% CI 0.90-20.89; p = .067). Moreover, CCL18 levels in effluent at year 3 of PD were independently associated with a risk of PMF development, adjusted for the classical (water and creatinine) peritoneal transport parameters. These trends were confirmed in a cross-sectional study of 61 long-term patients treated with PD. In conclusion, our study shows the diagnostic capacity of chemokine CCL18 levels in peritoneal effluent to predict PMF and suggests CCL18 as a new marker and mediator of this serious condition as well as a new potential therapeutic target.
dc.language.isoeng
dc.rightsopenAccess-
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBiomarkers
dc.subject.meshChemokines, CC
dc.subject.meshCreatinine
dc.subject.meshCross-Sectional Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLongitudinal Studies
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPeritoneal Dialysis
dc.subject.meshPeritoneal Fibrosis
dc.subject.meshPeritoneum
dc.subject.meshRetrospective Studies
dc.subject.meshRisk Factors
dc.subject.meshYoung Adult
dc.titleSustained low peritoneal effluent CCL18 levels are associated with preservation of peritoneal membrane function in peritoneal dialysis.
dc.typeArtículo
dc.identifier.pubmedID28414753
dc.format.volume12
dc.format.pagee0175835
dc.identifier.e-issn1932-6203
dc.identifier.journalPloS one
dc.identifier.doi10.1371/journal.pone.0175835
dc.format.number4
dc.identifier.pmcPMC5393879
dc.pubmedtypeJournal Article
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos
Hospitales > H. U. La Paz > Artículos

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