Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/39950
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dc.contributor.authorBustos-Morán, Eugenio
dc.contributor.authorBlas-Rus, Noelia
dc.contributor.authorMartin-Cófreces, Noa Beatriz
dc.contributor.authorSánchez-Madrid, Francisco
dc.date.accessioned2019-07-01T06:28:31Z-
dc.date.available2019-07-01T06:28:31Z-
dc.date.issued2017
dc.identifier.citationJ. Cell. Sci..2017 04;(130)7:1217-1223
dc.identifier.urihttps://hdl.handle.net/20.500.12530/39950-
dc.description.abstractThe immune synapse (IS) is a specialized structure formed at the contact area between T lymphocytes and antigen-presenting cells (APCs) that is essential for the adaptive immune response. Proper T cell activation requires its polarization towards the APC, which is highly dependent on the tubulin cytoskeleton. Microtubule-associated protein-4 (MAP4) is a microtubule (MT)-stabilizing protein that controls MTs in physiological processes, such as cell division, migration, vesicular transport or primary cilia formation. In this study, we assessed the role of MAP4 in T cell activation. MAP4 decorates the pericentrosomal area and MTs of the T cell, and it is involved in MT detyrosination and stable assembly in response to T cell activation. In addition, MAP4 prompts the timely translocation of the MT-organizing center (MTOC) towards the IS and the dynamics of signaling nanovesicles that sustains T cell activation. However, MAP4 acts as a negative regulator of other T cell activation-related signals, including diacylglycerol (DAG) production and IL2 secretion. Our data indicate that MAP4 acts as a checkpoint molecule that balances positive and negative hallmarks of T cell activation.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectMAP4
dc.subjectMicrotubules
dc.subjectT cell activation
dc.subjectVesicle dynamics
dc.subject.meshBiomarkers
dc.subject.meshDiglycerides
dc.subject.meshHumans
dc.subject.meshImmunological Synapses
dc.subject.meshJurkat Cells
dc.subject.meshLymphocyte Activation
dc.subject.meshMicrotubule-Associated Proteins
dc.subject.meshMicrotubule-Organizing Center
dc.subject.meshMicrotubules
dc.subject.meshNanoparticles
dc.subject.meshReceptors, Antigen, T-Cell
dc.subject.meshSignal Transduction
dc.subject.meshT-Lymphocytes
dc.subject.meshTransport Vesicles
dc.titleMicrotubule-associated protein-4 controls nanovesicle dynamics and T cell activation.
dc.typeArtículo
dc.identifier.pubmedID28209780
dc.format.volume130
dc.format.page1217-1223
dc.identifier.e-issn1477-9137
dc.identifier.journalJournal of cell science
dc.identifier.doi10.1242/jcs.199042
dc.format.number7
dc.identifier.pmcPMC5589067
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos

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