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Title: Antimicrobial Porous Surfaces Prepared by Breath Figures Approach.
Issue Date: 24-Jul-2018
Citation: Muñoz-Bonilla A, Cuervo-Rodríguez R, López-Fabal F, Gómez-Garcés JL, Fernández-García M. Antimicrobial Porous Surfaces Prepared by Breath Figures Approach. Materials (Basel). 2018 Jul 24;11(8):E1266
Abstract: Herein, efficient antimicrobial porous surfaces were prepared by breath figures approach from polymer solutions containing low content of block copolymers with high positive charge density. In brief, those block copolymers, which were used as additives, are composed of a polystyrene segment and a large antimicrobial block bearing flexible side chain with 1,3-thiazolium and 1,2,3-triazolium groups, PS54-b-PTTBM-M44, PS54-b-PTTBM-B44, having different alkyl groups, methyl or butyl, respectively. The antimicrobial block copolymers were blended with commercial polystyrene in very low proportions, from 3 to 9 wt %, and solubilized in THF. From these solutions, ordered porous films functionalized with antimicrobial cationic copolymers were fabricated, and the influence of alkylating agent and the amount of copolymer in the blend was investigated. Narrow pore size distribution was obtained for all the samples with pore diameters between 5 and 11 µm. The size of the pore decreased as the hydrophilicity of the system increased; thus, either as the content of copolymer was augmented in the blend or as the copolymers were quaternized with methyl iodide. The resulting porous polystyrene surfaces functionalized with low content of antimicrobial copolymers exhibited remarkable antibacterial efficiencies against Gram positive bacteria Staphylococcus aureus, and Candida parapsilosis fungi as microbial models.
PMID: 30042299
Rights: openAccess
ISSN: 1996-1944
Appears in Collections:Hospitales > H. U. de Móstoles > Artículos

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