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|Title:||Variation at FCGR2A and functionally related genes is associated with the response to anti-TNF therapy in rheumatoid arthritis.|
Tumor Necrosis Factor-alpha
Polymorphism, Single Nucleotide
|Abstract:||Anti-TNF therapies have been highly efficacious in the management of rheumatoid arthritis (RA), but 25-30% of patients do not show a significant clinical response. There is increasing evidence that genetic variation at the Fc receptor FCGR2A is associated with the response to anti-TNF therapy. We aimed to validate this genetic association in a patient cohort from the Spanish population, and also to identify new genes functionally related to FCGR2A that are also associated with anti-TNF response.|
|Appears in Collections:||Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos|
Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos
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