Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/41764

Title:	Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.
Authors:	Formentini, Laura Ryan, Alexander J Gálvez-Santisteban, Manuel Carter, Leslie Taub, Pam Lapek, John D Gonzalez, David J Villarreal, Francisco Ciaraldi, Theodore P Cuezva, José M Henry, Robert R View more
Keywords:	Energy metabolism H+-ATP synthase Inhibitory factor 1 (IF1) Mitochondria Obesity Skeletal muscle Type 2 diabetes View more
Mesh:	Diabetes Mellitus, Type 2 Dyslipidemias Female Humans Insulin Resistance Male Mitochondria, Muscle Mitochondrial Proton-Translocating ATPases Muscle, Skeletal Obesity Proteomics View more
Issue Date:	2017
Citation:	Diabetologia.2017 10;(60)10:2052-2065
Abstract:	Mitochondria are important regulators of the metabolic phenotype in type 2 diabetes. A key factor in mitochondrial physiology is the H+-ATP synthase. The expression and activity of its physiological inhibitor, ATPase inhibitory factor 1 (IF1), controls tissue homeostasis, metabolic reprogramming and signalling. We aimed to characterise the putative role of IF1 in mediating skeletal muscle metabolism in obesity and diabetes.
PMID:	28770317
URI:	https://hdl.handle.net/20.500.12530/41764
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos

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