Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/41808
Title: Interorganelle Communication between Mitochondria and the Endolysosomal System.
Authors: 
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Issue Date: 2017
Citation: Front Cell Dev Biol.2017;(5):95
Abstract: The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation. Here, we present what is currently known about the functional and physical communication between mitochondria and lysosomes or lysosome-related organelles, and their role in sustaining cellular homeostasis.
PMID: 29164114
URI: https://hdl.handle.net/20.500.12530/41808
Rights: openAccess
ISSN: 2296-634X
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos

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