Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/41855

Title:	Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models.
Authors:	Solana, José Carlos Ramírez, Laura Corvo, Laura de Oliveira, Camila Indiani Barral-Netto, Manoel Requena, José María Iborra, Salvador Soto, Manuel View more
Mesh:	Animals Female HSP70 Heat-Shock Proteins Interferon-gamma Interleukin-4 Leishmania infantum Leishmania major Leishmaniasis, Cutaneous Mice Mice, Inbred BALB C Mice, Inbred C57BL Mutation Parasite Load Protozoan Vaccines T-Lymphocytes Vaccines, Attenuated View more
Issue Date:	May-2017
Citation:	PLoS Negl Trop Dis.2017 May;(11)5:e0005644
Abstract:	The immunization with genetically attenuated Leishmania cell lines has been associated to the induction of memory and effector T cell responses against Leishmania able to control subsequent challenges. A Leishmania infantum null mutant for the HSP70-II genes has been described, possessing a non-virulent phenotype.
PMID:	28558043
URI:	https://hdl.handle.net/20.500.12530/41855
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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