Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/42004
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dc.contributor.authorRogers, Natasha M
dc.contributor.authorGhimire, Kedar
dc.contributor.authorCalzada, Maria J
dc.contributor.authorIsenberg, Jeffrey S
dc.date.accessioned2019-08-29T08:51:08Z-
dc.date.available2019-08-29T08:51:08Z-
dc.date.issued2017-07-01
dc.identifier.citationCardiovasc. Res..2017 Jul;(113)8:858-868
dc.identifier.urihttps://hdl.handle.net/20.500.12530/42004-
dc.description.abstractMatricellular proteins are secreted molecules that have affinities for both extracellular matrix and cell surface receptors. Through interaction with structural proteins and the cells that maintain the matrix these proteins can alter matrix strength. Matricellular proteins exert control on cell activity primarily through engagement of membrane receptors that mediate outside-in signaling. An example of this group is thrombospondin-1 (TSP1), first identified as a component of the secreted product of activated platelets. As a result, TSP1 was initially studied in relation to coagulation, growth factor signaling and angiogenesis. More recently, TSP1 has been found to alter the effects of the gaseous transmitter nitric oxide (NO). This latter capacity has provided motivation to study TSP1 in diseases associated with loss of NO signaling as observed in cardiovascular disease and pulmonary hypertension (PH). PH is characterized by progressive changes in the pulmonary vasculature leading to increased resistance to blood flow and subsequent right heart failure. Studies have linked TSP1 to pre-clinical animal models of PH and more recently to clinical PH. This review will provide analysis of the vascular and non-vascular effects of TSP1 that contribute to PH, the experimental and translational studies that support a role for TSP1 in disease promotion and frame the relevance of these findings to therapeutic strategies.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectCD47
dc.subjectEndothelin-1
dc.subjectNitric  oxide
dc.subjectNox1
dc.subjectPulmonary  hypertension
dc.subjectROS
dc.subjectThrombospondin-1
dc.subjectVasorelaxation
dc.subjectcMyc
dc.subjecteNOS
dc.subject.meshAnimals
dc.subject.meshCD47 Antigen
dc.subject.meshHumans
dc.subject.meshHypertension, Pulmonary
dc.subject.meshNitric Oxide
dc.subject.meshRegional Blood Flow
dc.subject.meshSignal Transduction
dc.subject.meshThrombospondin 1
dc.titleMatricellular protein thrombospondin-1 in pulmonary hypertension: multiple pathways to disease.
dc.typeArtículo
dc.identifier.pubmedID28472457
dc.format.volume113
dc.format.page858-868
dc.identifier.e-issn1755-3245
dc.identifier.journalCardiovascular research
dc.identifier.doi10.1093/cvr/cvx094
dc.format.number8
dc.identifier.pmcPMC5852507
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos

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