Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/42015
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dc.contributor.authorMachado-Pineda, Yesenia
dc.contributor.authorCardeñes, Beatriz
dc.contributor.authorReyes, Raquel
dc.contributor.authorLópez-Martín, Soraya
dc.contributor.authorToribio, Víctor
dc.contributor.authorSánchez-Organero, Paula
dc.contributor.authorSuarez, Henar
dc.contributor.authorGrötzinger, Joachim
dc.contributor.authorLorenzen, Inken
dc.contributor.authorYáñez-Mó, María
dc.contributor.authorCabañas, Carlos
dc.date.accessioned2019-08-29T08:51:45Z-
dc.date.available2019-08-29T08:51:45Z-
dc.date.issued2018
dc.identifier.citationFront Immunol.2018;(9):2474
dc.identifier.urihttps://hdl.handle.net/20.500.12530/42015-
dc.description.abstractIntegrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-receptor, the metalloproteinase ADAM17/TACE. Interactions between integrin α5β1 and ADAM17 may take place both in trans (between molecules expressed on different cells) or in cis (between molecules expressed on the same cell) configurations. It has been recently reported that the cis association between α5β1 and ADAM17 keeps both molecules inactive, whereas their dissociation results in activation of their adhesive and metalloproteinase activities. Here we show that the tetraspanin CD9 negatively regulates integrin α5β1-mediated cell adhesion by enhancing the cis interaction of this integrin with ADAM17 on the cell surface. Additionally we show that, similarly to CD9, the monoclonal antibody 2A10 directed to the disintegrin domain of ADAM17 specifically inhibits integrin α5β1-mediated cell adhesion to its ligands fibronectin and ADAM17.
dc.language.isoeng
dc.rightsopenAccess-
dc.subjectADAM17
dc.subjectCD9
dc.subjectcell adhesion
dc.subjectfibronectin
dc.subjectintegrin
dc.subjectmetalloproteinase
dc.subjecttetraspanin
dc.subjectα5β1
dc.titleCD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17.
dc.typeArtículo
dc.identifier.pubmedID30455686
dc.format.volume9
dc.format.page2474
dc.identifier.e-issn1664-3224
dc.identifier.journalFrontiers in immunology
dc.identifier.doi10.3389/fimmu.2018.02474
dc.identifier.pmcPMC6230984
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos

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