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Title: A potential role for estrogen in cigarette smoke-induced microRNA alterations and lung cancer.
Issue Date: Jun-2016
Citation: Transl Lung Cancer Res.2016 Jun;(5)3:322-30
Abstract: Alteration in the expression of microRNAs (miRNAs) is associated with oncogenesis and cancer progression. In this review we aim to suggest that elevated levels of estrogens and their metabolites inside the lungs as a result of cigarette smoke exposure can cause widespread repression of miRNA and contribute to lung tumor development. Anti-estrogenic compounds, such as the components of cruciferous vegetables, can attenuate this effect and potentially reduce the risk of lung cancer (LC) among smokers.
PMID: 27413713
Rights: openAccess
ISSN: 2218-6751
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos

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