Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/42798
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dc.contributor.authorJacovas, Vanessa Cristina
dc.contributor.authorRovaris, Diego Luiz
dc.contributor.authorPeréz, Orlando
dc.contributor.authorde Azevedo, Soledad
dc.contributor.authorMacedo, Gabriel Souza
dc.contributor.authorSandoval, José Raul
dc.contributor.authorSalazar-Granara, Alberto
dc.contributor.authorVillena, Mercedes
dc.contributor.authorDugoujon, Jean-Michel
dc.contributor.authorBisso-Machado, Rafael
dc.contributor.authorPetzl-Erler, Maria Luiza
dc.contributor.authorSalzano, Francisco Mauro
dc.contributor.authorAshton-Prolla, Patricia
dc.contributor.authorRamallo, Virginia
dc.contributor.authorBortolini, Maria Cátira
dc.date.accessioned2019-08-29T11:13:28Z-
dc.date.available2019-08-29T11:13:28Z-
dc.date.issued2015
dc.identifier.citationPLoS ONE.2015;(10)9:e0137823
dc.identifier.urihttps://hdl.handle.net/20.500.12530/42798-
dc.description.abstractThe diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantani, Anapia, Uros, Guarani Ñandeva, and Guarani Kaiowá populations, characterized as Native American or as having a high level (> 90%) of Native American ancestry. In addition, published data pertaining to 100 persons from five other Native American populations (Surui, Karitiana, Maya, Pima, and Piapoco) were analyzed. The populations were classified as living in high altitude (≥ 2,500 m) or in lowlands (< 2,500 m). Our analyses revealed that alleles USP7-G, LIF-T, and MDM2-T showed significant evidence that they were selected for in relation to harsh environmental variables related to high altitudes. Our results show for the first time that alleles of classical TP53 network genes have been evolutionary co-opted for the successful human colonization of the Andes.
dc.language.isoeng
dc.rightsopenAccess-
dc.subject.meshAcclimatization
dc.subject.meshAltitude
dc.subject.meshHumans
dc.subject.meshIndians, North American
dc.subject.meshTumor Suppressor Protein p53
dc.subject.meshPolymorphism, Single Nucleotide
dc.titleGenetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.
dc.typeArtículo
dc.identifier.pubmedID26382048
dc.format.volume10
dc.format.pagee0137823
dc.identifier.e-issn1932-6203
dc.identifier.journalPloS one
dc.identifier.doi10.1371/journal.pone.0137823
dc.format.number9
dc.identifier.pmcPMC4575214
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos

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