HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/42886

Title:	HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration.
Authors:	Aguado, A Rodríguez, C Martínez-Revelles, S Avendaño, M S Zhenyukh, O Orriols, M Martínez-González, J Alonso, M J Briones, A M Dixon, D A Salaices, M View more
Mesh:	Angiotensin II Animals Aorta Celecoxib Cell Movement Cyclooxygenase 2 Drug Synergism ELAV-Like Protein 1 Gene Expression Regulation Humans Interleukin-1beta Male Mice Mice, Inbred C57BL Muscle, Smooth, Vascular RNA Stability RNA, Messenger Rats Rats, Sprague-Dawley Tenascin Vascular Remodeling View more
Issue Date:	Jun-2015
Citation:	Br. J. Pharmacol..2015 Jun;(172)12:3028-42
Abstract:	Angiotensin II (AngII) and IL-1β are involved in cardiovascular diseases through the induction of inflammatory pathways. HuR is an adenylate- and uridylate-rich element (ARE)-binding protein involved in the mRNA stabilization of many genes. This study investigated the contribution of HuR to the increased expression of COX-2 induced by AngII and IL-1β and its consequences on VSMC migration and remodelling.
PMID:	25653183
URI:	https://hdl.handle.net/20.500.12530/42886
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos

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