Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/43209
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dc.contributor.authorCorrea-Rocha, Rafael
dc.contributor.authorLopez-Abente, Jacobo
dc.contributor.authorGutierrez, Carolina
dc.contributor.authorPérez-Fernández, Verónica Astrid
dc.contributor.authorPrieto-Sánchez, Adrián
dc.contributor.authorMoreno-Guillen, Santiago
dc.contributor.authorMuñoz-Fernández, María-Ángeles
dc.contributor.authorPion, Marjorie
dc.date.accessioned2019-08-29T12:24:29Z-
dc.date.available2019-08-29T12:24:29Z-
dc.date.issued2018
dc.identifier.citationPLoS ONE.2018;(13)8:e0203419
dc.identifier.urihttps://hdl.handle.net/20.500.12530/43209-
dc.description.abstractIn our work, we analyzed the role of the CD100/CD72 and PD-1/PD-L1 axes in immune response dysfunction in human immunodeficiency virus (HIV)-1 infection in which high expressions of PD-1 and PD-L1 were associated with an immunosuppressive state via limitation of the HIV-1-specific T-cell responses. CD100 was demonstrated to play a relevant role in immune responses in various pathological processes and may be responsible for immune dysregulation during HIV-1 infection. We investigated the function of CD72/CD100, and PD-1/PDL-1 axes on T and B cells in HIV-infected individuals and in healthy individuals. We analyzed the frequencies and fluorescence intensities of these four markers on CD4+, CD8+ T and B cells. Marker expressions were increased during active HIV-1 infection. CD100 frequency on T cells was positively associated with the expression of PD-1 and PD-L1 on T cells from HIV-infected treatment-naïve individuals. In addition, the frequency of CD72-expressing T cells was associated with interferon gamma (IFN-γ) production in HIV-infected treatment-naïve individuals. Our data suggest that the CD72/CD100 and PD-1/PD-L1 axes may jointly participate in dysregulation of immunity during HIV-1 infection and could partially explain the immune systems' hyper-activation and exhaustion.
dc.language.isoeng
dc.rightsopenAccess-
dc.subject.meshAdult
dc.subject.meshAntigens, CD
dc.subject.meshAntigens, Differentiation, B-Lymphocyte
dc.subject.meshB-Lymphocytes
dc.subject.meshB7-H1 Antigen
dc.subject.meshBiomarkers
dc.subject.meshFemale
dc.subject.meshHIV Infections
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshProgrammed Cell Death 1 Receptor
dc.subject.meshSemaphorins
dc.subject.meshT-Lymphocytes
dc.subject.meshViremia
dc.subject.meshYoung Adult
dc.subject.meshHIV-1
dc.titleCD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.
dc.typeArtículo
dc.identifier.pubmedID30161254
dc.format.volume13
dc.format.pagee0203419
dc.identifier.e-issn1932-6203
dc.identifier.journalPloS one
dc.identifier.doi10.1371/journal.pone.0203419
dc.format.number8
dc.identifier.pmcPMC6117071
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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