Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/54356
Title: Breast cancer PAM50 signature: correlation and concordance between RNA-Seq and digital multiplexed gene expression technologies in a triple negative breast cancer series
Authors: 
Filiation: Instituto de Investigación Sanitaria Gregorio Marañón
Keywords: 
Mesh: 
Issue Date: 3-Jun-2019
Publisher: BioMed Central
Citation: Breast cancer PAM50 signature: correlation and concordance between RNA-Seq and digital multiplexed gene expression technologies in a triple negative breast cancer series
Abstract: Full RNA-Seq is a fundamental research tool for whole transcriptome analysis. However, it is too costly and time consuming to be used in routine clinical practice. We evaluated the transcript quantification agreement between RNA-Seq and a digital multiplexed gene expression platform, and the subtype call after running the PAM50 assay in a series of breast cancer patients classified as triple negative by IHC/FISH. The goal of this study is to analyze the concordance between both expression platforms overall, and for calling PAM50 triple negative breast cancer intrinsic subtypes in particular.
PMID: 31159741
URI: https://hdl.handle.net/20.500.12530/54356
Rights: info:eu-repo/semantics/openAccess
ISSN: 1471-2164
Appears in Collections:Hospitales > H. U. Gregorio Marañón > Artículos

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