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Title: Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
Subdirección General de Investigación Sanitaria y Documentación, Consejería de Sanidad, Madrid, Spain.
Fundación de Investigación e Innovación Biosanitaria de Atención Primaria, Madrid, Spain.
Sistemas de Información, Gerencia Asistencial de Atención Primaria Madrid, Madrid, Spain.
Instituto de Investigación Sanitaria Hospital Clínico de San Carlos (IdISSC), Madrid, Spain.
Hospital Central de la Defensa, Madrid, Spain.
Instituto de Investigación Sanitaria Hospital Clínico de San Carlos (IdISSC), Madrid, Spain.
Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Keywords: diabetes tipo 2 mellitus,
Mesh: Diabetes Mellitus, Type 2
Cie10: Diabetes mellitus, no especificada (E14 )
Decs: Diabetes Mellitus
Issue Date: 27-Jul-2021
Citation: Sci Rep.2021 Jul;(11)1:15245
Abstract: We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90-1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65-85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88-6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).
PMID: 34315938
Rights: info:eu-repo/semantics/openAccess
Atribución-NoComercial 3.0 España
ISSN: 2045-2322
Appears in Collections:Otros centros dependientes de la Consejería de Sanidad > Direcciones Generales > Artículos

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