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Title: Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours
Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Sociedad Española de Oncología Médica (SEOM)
Hospital Universitario Ramón y Cajal, Universidad de Alcalá, IRYCIS, CIBERONC, Madrid, Spain
Sociedad Española de Hematología y Oncologías Pediátricas (SEHOP)
Hospital Universitario Vall d'Hebron, Barcelona, Spain.
Sociedad Española de Anatomía Patológica (SEAP)
Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBiS), CSIC, Facultad de Medicina, Universidad de Sevilla, CIBERONC, Sevilla, Spain.
Instituto Investigación Sanitaria Gregorio Marañon (IISGM), Madrid, Spain.
Sociedad Española de Hematología y Oncologías Pediátricas (SEHOP)
Sociedad Española de Anatomía Patológica (SEAP)
IIS-Fundación Universitaria Jiménez Díaz, CIBERONC, Madrid, Spain.
Issue Date: Aug-2021
Publisher: Springer Science and Business Media LLC
Citation: Clin Transl Oncol.2021 Aug;(23)8:1529-1541
Abstract: The recent identification of rearrangements of neurotrophic tyrosine receptor kinase (NTRK) genes and the development of specific fusion protein inhibitors, such as larotrectinib and entrectinib, have revolutionised the diagnostic and clinical management of patients presenting with tumours with these alterations. Tumours that harbour NTRK fusions are found in both adults and children; and they are either rare tumours with common NTRK fusions that may be diagnostic, or more prevalent tumours with rare NTRK fusions. To assess currently available evidence on this matter, three key Spanish medical societies (the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Pathological Anatomy (SEAP), and the Spanish Society of Paediatric Haematology and Oncology (SEHOP) have brought together a group of experts to develop a consensus document that includes guidelines on the diagnostic, clinical, and therapeutic aspects of NTRK-fusion tumours. This document also discusses the challenges related to the routine detection of these genetic alterations in a mostly public Health Care System.
PMID: 33620682
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Fundaciones e Institutos de Investigación > FIB H. Infantil U. Niño Jesús > Artículos

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