Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/54655
Title: Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells)
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Hospital Universitario de Fuenlabrada. Servicio de Farmacia
Hospital Universitario de Fuenlabrada. Servicio de Digestivo
Hospital Universitario de Fuenlabrada. Servicio de Medicina Interna
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Issue Date: 8-May-2022
Publisher: MDPI AG
Citation: Lapuente JP, Gómez G, Marco-Brualla J, Fernández P, Desportes P, Sanz J, et al. Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells). Biomedicines [Internet]. 2022 May 8;10(5):1094. Available from: http://dx.doi.org/10.3390/biomedicines10051094
Abstract: Our research group has been developing a series of biological drugs produced by coculture techniques with M2-polarized macrophages with different primary tissue cells and/or mesenchymal stromal cells (MSC), generally from fat, to produce anti-inflammatory and anti-fibrotic effects, avoiding the overexpression of pro-inflammatory cytokines by the innate immune system at a given time. One of these products is the drug PRS CK STORM, a medium conditioned by allogenic M2-polarized macrophages, from coculture, with those macrophages M2 with MSC from fat, whose composition, in vitro safety, and efficacy we studied. In the present work, we publish the results obtained in terms of safety (pharmacodynamics and pharmacokinetics) and efficacy of the intravenous application of this biological drug in a murine model of cytokine storm associated with severe infectious processes, including those associated with COVID-19. The results demonstrate the safety and high efficacy of PRS CK STORM as an intravenous drug to prevent and treat the cytokine storm associated with infectious processes, including COVID-19.
URI: https://hdl.handle.net/20.500.12530/54655
Rights: info:eu-repo/semantics/openAccess
Atribución 3.0 España
ISSN: 2227-9059
Appears in Collections:Hospitales > H. U. de Fuenlabrada > Artículos

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