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|Title:||Efficacy of belimumab in Primary Sjögren's syndrome: A systematic review.|
B-cell targeted therapy
Primary Sjögren's syndrome
Síndrome de Sjögren primario
Terapia dirigida frente a células B
|Citation:||Reumatol Clin (Engl Ed).2021 Mar;(17)3:170-174|
|Abstract:||To evaluate the efficacy and safety of belimumab in patients with Primary Sjögren's syndrome (pSS). The search included manuscripts assessing the efficacy or safety of belimumab in patients with pSS (American-European Consensus Criteria 2002) published between 2004 and 2017 in MEDLINE, EMBASE or Cochrane databases. Two reviewers independently selected the articles, extracted data and evaluated the quality of the evidence following Scottish Intercollegiate Guidelines Network (SIGN) recommendation grades. Out of 135 citations, only 3 articles were included. All of them publishing results from the same study at different time points including 28 patients. At week 28 improvement was reported for visual analogue scale (VAS) dryness score and glandular manifestations in 37% and 77% of patients, respectively, which persisted at week 52 (W52). Belimumab was well tolerated and safely administered. Published evidence to determine the efficacy of belimumab in pSS is limited. Belimumab seems to be effective to reduce systemic activity, parotid enlargement, lymphadenopathies, articular manifestation and B cell biomarkers.|
|Appears in Collections:||Fundaciones e Institutos de Investigación > FIIB H. U. Infanta Sofía y H. U. Henares > Artículos|
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