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dc.contributor.authorTejera Segura, Beatriz
dc.contributor.authorAltabás González, Irene
dc.contributor.authorRúa-Figueroa, Iñigo
dc.contributor.authorPérez Veiga, Natalia
dc.contributor.authorDel Campo Pérez, Victor
dc.contributor.authorOlivé-Marqués, Alejandro
dc.contributor.authorGalindo, María
dc.contributor.authorCalvo, Jaime
dc.contributor.authorOvalles-Bonilla, Juan Gabriel
dc.contributor.authorFernández-Nebro, Antonio
dc.contributor.authorMenor-Almagro, Raúl
dc.contributor.authorTomero, Eva
dc.contributor.authorDel Val Del Amo, Natividad
dc.contributor.authorUriarte Isacelaya, Esther
dc.contributor.authorMartínez-Taboada, Víctor Manuel
dc.contributor.authorAndreu, Jose L
dc.contributor.authorBoteanu, Alina
dc.contributor.authorNarváez, Javier
dc.contributor.authorMovasat, Atusa
dc.contributor.authorMontilla, Carlos
dc.contributor.authorSenabre Gallego, Jose Miguel
dc.contributor.authorHernández-Cruz, Blanca
dc.contributor.authorAndrés, Mariano
dc.contributor.authorSalgado, Eva
dc.contributor.authorFreire, Mercedes
dc.contributor.authorMachín García, Sergio
dc.contributor.authorMoriano, Clara
dc.contributor.authorExpósito, Lorena
dc.contributor.authorPérez Velásquez, Clara
dc.contributor.authorVelloso-Feijoo, M L
dc.contributor.authorCacheda, Ana Paula
dc.contributor.authorLozano-Rivas, Nuria
dc.contributor.authorBonilla, Gema
dc.contributor.authorArévalo, Marta
dc.contributor.authorJiménez, Inmaculada
dc.contributor.authorQuevedo-Vila, Víctor
dc.contributor.authorManero-Ruiz, Francisco J
dc.contributor.authorGarcía de la Peña Lefebvre, Paloma
dc.contributor.authorVázquez-Rodríguez, Tomás Ramón
dc.contributor.authorIbañez-Rua, Jesús
dc.contributor.authorCobo-Ibañez, Tatiana
dc.contributor.authorPego-Reigosa, Jose María
dc.identifier.citationRheumatology (Oxford).2021;(60)11:5329-5336
dc.description.abstractSLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis. We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil ≥4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease. From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients. Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage.
dc.subjectgastrointestinal disease
dc.subjectsystemic lupus erythematosus
dc.subject.meshDigestive System Diseases
dc.subject.meshLupus Erythematosus, Systemic
dc.subject.meshMiddle Aged
dc.subject.meshRetrospective Studies
dc.subject.meshYoung Adult
dc.titleRelevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?
dc.identifier.journalRheumatology (Oxford, England)
dc.identifier.journalabbreviationRheumatology (Oxford)
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos
Hospitales > H. U. 12 de Octubre > Artículos
Hospitales > H. U. Puerta de Hierro Majadahonda > Artículos
Hospitales > H. U. Príncipe de Asturias > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos
Fundaciones e Institutos de Investigación > FIIB H. U. Infanta Sofía y H. U. Henares > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos
Hospitales > H. U. Infanta Sofía > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos
Hospitales > H. U. La Paz > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. Puerta de Hierro-Segovia de Arana > Artículos

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