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dc.contributor.authorZambrana, Francisco
dc.contributor.authorCarril-Ajuria, Lucia
dc.contributor.authorGómez de Liaño, Alfonso
dc.contributor.authorMartinez Chanza, Nieves
dc.contributor.authorManneh, Ray
dc.contributor.authorCastellano, Daniel
dc.contributor.authorde Velasco, Guillermo
dc.identifier.citationCancer Treat Rev.2021;(99):102239
dc.description.abstractImmune-checkpoint inhibitor-based therapy has revolutionized the natural history of metastatic renal cell carcinoma (mRCC) providing better survival outcomes, higher rates of complete responses (CR) and durable remissions. Along with these advances, new challenges have emerged. RECIST and new immune-response criteria may be equivocal identifying complete responses. How to define a durable response and what is the optimal treatment duration remains unclear. Furthermore, the real value of a complete and deep response, whether or not it can be considered curation and whether or not immunotherapy discontinuation should be considered after complete response, are questions that remain open. The present article reviews the current evidence regarding the impact and challenges of managing complete and durable responses in mRCC treated with immune-checkpoint inhibitors.
dc.subjectComplete response
dc.subjectImmune checkpoint inhibitors
dc.subjectKidney cancer
dc.subjectRenal cell carcinoma
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshCarcinoma, Renal Cell
dc.subject.meshClinical Trials, Phase III as Topic
dc.subject.meshImmune Checkpoint Inhibitors
dc.subject.meshKidney Neoplasms
dc.subject.meshRandomized Controlled Trials as Topic
dc.titleComplete response and renal cell carcinoma in the immunotherapy era: The paradox of good news.
dc.identifier.journalCancer treatment reviews
dc.identifier.journalabbreviationCancer Treat Rev
dc.pubmedtypeJournal Article
Appears in Collections:Hospitales > H. U. 12 de Octubre > Artículos
Fundaciones e Institutos de Investigación > IIS H. U. 12 de Octubre > Artículos
Fundaciones e Institutos de Investigación > FIIB H. U. Infanta Sofía y H. U. Henares > Artículos
Hospitales > H. U. Infanta Sofía > Artículos

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