Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/55909
Title: Permutation Entropy and Irreversibility in Gait Kinematic Time Series from Patients with Mild Cognitive Decline and Early Alzheimer's Dementia
Authors: 
Filiation: 
[Martin-Gonzalo, Juan-Andres] Univ Autonoma Madrid, Escuela Fisioterapia Once, Madrid 28034, Spain
[Martin-Gonzalo, Juan-Andres] Univ Autonoma Madrid, Dept Anat Histol & Neurociencia, Madrid 28029, Spain
[Pulido-Valdeolivas, Irene] Univ Autonoma Madrid, Dept Anat Histol & Neurociencia, Madrid 28029, Spain
[Wang, Yu] Univ Autonoma Madrid, Dept Anat Histol & Neurociencia, Madrid 28029, Spain
[Wang, Ting] Univ Autonoma Madrid, Dept Anat Histol & Neurociencia, Madrid 28029, Spain
[Rausell, Estrella] Univ Autonoma Madrid, Dept Anat Histol & Neurociencia, Madrid 28029, Spain
[Gomez-Andres, David] Univ Autonoma Madrid, Dept Anat Histol & Neurociencia, Madrid 28029, Spain
[Pulido-Valdeolivas, Irene] Hosp Clin Barcelona, Visual Pathway Lab, Neuroimmunol Ctr, Biomed Res Ctr August Pi i Sunyer IDIBAPS, E-08036 Barcelona, Spain
[Pulido-Valdeolivas, Irene] Hosp Clin Barcelona, Neurol Dept, Biomed Res Ctr August Pi i Sunyer IDIBAPS, E-08036 Barcelona, Spain
[Chiclana-Actis, Guadalupe] Hosp Univ Infanta Sofia, Serv Neurol, Unidad Trastornos Cognit, Madrid 28702, Spain
[del Carmen Algarra-Lucas, Maria] Hosp Univ Infanta Sofia, Serv Neurol, Unidad Trastornos Cognit, Madrid 28702, Spain
[Palmi-Cortes, Itziar] Hosp Univ Infanta Sofia, Serv Neurol, Unidad Trastornos Cognit, Madrid 28702, Spain
[Fernandez Travieso, Jorge] Hosp Univ Infanta Sofia, Serv Neurol, Unidad Trastornos Cognit, Madrid 28702, Spain
[Dolores Torrecillas-Narvaez, Maria] Hosp Univ Infanta Sofia, Serv Neurol, Unidad Trastornos Cognit, Madrid 28702, Spain
[Miralles-Martinez, Ambrosio A.] Hosp Univ Infanta Sofia, Serv Neurol, Unidad Trastornos Cognit, Madrid 28702, Spain
[Gomez-Andres, David] Vall dHebron Univ Hosp, Paediat Neurol, Barcelona 08035, Spain
[Gomez-Andres, David] VHIR Euro NMD, ERN RND, Barcelona 08035, Spain
[Zanin, Massimiliano] Univ Politecn Madrid, Ctr Tecnol Biomed, Madrid 28223, Spain
Keywords: 
Issue Date: 1-Sep-2019
Publisher: Mdpi
Abstract: Gait is a basic cognitive purposeful action that has been shown to be altered in late stages of neurodegenerative dementias. Nevertheless, alterations are less clear in mild forms of dementia, and the potential use of gait analysis as a biomarker of initial cognitive decline has hitherto mostly been neglected. Herein, we report the results of a study of gait kinematic time series for two groups of patients (mild cognitive impairment and mild Alzheimer's disease) and a group of matched control subjects. Two metrics based on permutation patterns are considered, respectively measuring the complexity and irreversibility of the time series. Results indicate that kinematic disorganisation is present in early phases of cognitive impairment; in addition, they depict a rich scenario, in which some joint movements display an increased complexity and irreversibility, while others a marked decrease. Beyond their potential use as biomarkers, complexity and irreversibility metrics can open a new door to the understanding of the role of the nervous system in gait, as well as its adaptation and compensatory mechanisms.
URI: https://hdl.handle.net/20.500.12530/55909
Appears in Collections:Fundaciones e Institutos de Investigación > FIIB H. U. Infanta Sofía y H. U. Henares > Artículos

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