Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/55910
Title: Long-Term Experience with Hyperthermic Chemotherapy (HIVEC) Using Mitomycin-C in Patients with Non-Muscle Invasive Bladder Cancer in Spain
Authors: 
Filiation: 
[Plata, Ana] Hosp Univ Canarias, Urol Dept, Carretera Ofra S-N, San Cristobal De Laguna 38320, Spain
[Garcia, Carlos] Hosp Univ Canarias, Urol Dept, Carretera Ofra S-N, San Cristobal De Laguna 38320, Spain
[Guerrero-Ramos, Felix] Hosp Univ 12 Octubre, Urol Dept, Ave Cordoba S-N, Madrid 28041, Spain
[Gonzalez-Diaz, Alejandro] Hosp Univ 12 Octubre, Urol Dept, Ave Cordoba S-N, Madrid 28041, Spain
[Gonzalez-Valcarcel, Ignacio] Hosp Univ Infanta Sofia, Urol Dept, Paseo Europa 34, Madrid 28702, Spain
[de la Morena, Jose Manuel] Hosp Univ Infanta Sofia, Urol Dept, Paseo Europa 34, Madrid 28702, Spain
[Diaz-Goizueta, Francisco Javier] Hosp Univ Getafe, Urol Dept, Km 12-500, Madrid 28905, Spain
[Angulo, Javier C.] Hosp Univ Getafe, Urol Dept, Km 12-500, Madrid 28905, Spain
[del Alamo, Julio Fernandez] Hosp Univ Torrejon, Urol Dept, Mateo Inurria S-N, Madrid 28850, Spain
[Gonzalo, Victoria] Hosp Univ Burgos, Urol Dept, Ave Islas Baleares 3, Burgos 09006, Spain
[Montero, Javier] Hosp Univ Burgos, Urol Dept, Ave Islas Baleares 3, Burgos 09006, Spain
[Sousa-Escandon, Alejandro] Hosp Comarcal Monforte, Urol Dept, Rua Corredoira S-N, Monforte De Lemos 27400, Spain
[Leon, Juan] Hosp Comarcal Monforte, Urol Dept, Rua Corredoira S-N, Monforte De Lemos 27400, Spain
[Pontones, Jose Luis] Hosp Univ La Fe, Urol Dept, Avinguda Fernando Abril Martorell 106, Valencia 46026, Spain
[Delgado, Francisco] Hosp Univ La Fe, Urol Dept, Avinguda Fernando Abril Martorell 106, Valencia 46026, Spain
[Adriazola, Miguel] Hosp Gen Rio Carr, Urol Dept, Ave Donantes Sangre S-N, Palencia 34005, Spain
[Pascual, Angela] Hosp Gen Rio Carr, Urol Dept, Ave Donantes Sangre S-N, Palencia 34005, Spain
[Calleja, Jesus] Hosp Clin Univ Valladolid, Urol Dept, Paseo Castellana 261, Madrid 28046, Spain
[Ruano, Ana] Hosp Clin Univ Valladolid, Urol Dept, Paseo Castellana 261, Madrid 28046, Spain
[Martinez-Pineiro, Luis] Hosp Univ La Paz, Urol Dept, Paseo Castellana 261, Madrid 28905, Spain
[Angulo, Javier C.] Univ Europea Madrid, Fac Ciencias Biomed, Clin Dept, Carretera Toledo,Km 12-500, Madrid 28905, Spain
Keywords: 
Issue Date: 1-Nov-2021
Publisher: Mdpi
Abstract: (1) Background: Intravesical mitomycin-C (MMC) combined with hyperthermia is increasingly used in non-muscle invasive bladder cancer (NMIBC), especially in the context of a relative BCG shortage. We aim to determine real-world data on the long-term treatment outcomes of adjunct hyperthermic intravesical chemotherapy (HIVEC) with MMC and a COMBAT (R) bladder recirculation system (BRS); (2) Methods: A prospective observational trial was performed on patients with NMIBC treated with HIVEC using BRS in nine academic institutions in Spain between 2012-2020 (HIVEC-E). Treatment effectiveness (recurrence, progression and overall mortality) was evaluated in patients treated with HIVEC MMC 40mg in the adjuvant setting, with baseline data and a clinical follow-up, that comprise the Full Analysis Set (FAS). Safety, according to the number and severity of adverse effects (AEs), was evaluated in the safety (SAF) population, composed by patients with at least one adjunct HIVEC MMC instillation; (3) Results: The FAS population (n = 502) received a median number of 8.78 & PLUSMN; 3.28 (range 1-20) HIVEC MMC instillations. The median follow-up duration was 24.5 & PLUSMN; 16.5 (range 1-81) months. Its distribution, based on EAU risk stratification, was 297 (59.2%) for intermediate and 205 (40.8%) for high-risk. The figures for five-year recurrence-free and progression-free survival were 50.37% (53.3% for intermediate and 47.14% for high-risk) and 89.83% (94.02% for intermediate and 84.23% for high-risk), respectively. A multivariate analysis identified recurrent tumors (HR 1.83), the duration of adjuvant HIVEC therapy
URI: https://hdl.handle.net/20.500.12530/55910
Appears in Collections:Fundaciones e Institutos de Investigación > FIIB H. U. Infanta Sofía y H. U. Henares > Artículos

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