Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/55991
Title: Digestive involvement in primary Sjogren's syndrome: analysis from the Sjogrenser registry
Authors: 
Filiation: 
[Melchor, S.] Hosp Univ Doce Octubre, Rheumatol Dept, Madrid, Spain
[Carreira, P. E.] Hosp Univ Doce Octubre, Rheumatol Dept, Madrid, Spain
[Sanchez-Piedra, C.] SER, Unidad Invest, Madrid, Spain
[Fernandez Castro, M.] Hosp Univ Puerta Hierro Majadahonda, Madrid, Spain
[Andreu, J. L.] Hosp Univ Puerta Hierro Majadahonda, Madrid, Spain
[Martinez Taboada, V.] Univ Cantabria, Fac Med, Hosp Univ Marques Valdecilla, Santander, Spain
[Loricera, J.] Univ Cantabria, Fac Med, Hosp Univ Marques Valdecilla, Santander, Spain
[Olive, A.] Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
[Rosas, J.] Hosp Marina Baixa, Alicante, Spain
[Menor, R.] Hosp Gen Jerez de la Frontera, Cadiz, Spain
[Garcia-Aparicio, A.] Hosp Virgen de la Salud, Toledo, Spain
[Lopez Longo, F. J.] Hosp Univ Gregorio Maranon, Madrid, Spain
[Manrique-Arija, S.] Hosp Univ Carlos Haya, Malaga, Spain
[Garcia Vadillo, J. A.] Hosp Univ Princesa, Madrid, Spain
[Lopez-Gonzalez, R.] Hosp Virgen de la Concha, Zamora, Spain
[Narvaez, J.] Hosp Univ Bellvitge, Barcelona, Spain
[Galisteo, C.] Hosp Univ Parc Tauli, Barcelona, Spain
[Gonzalez Martin, J.] Hosp Univ Madrid Norte Sanchinarro, Madrid, Spain
[Naranjo, A.] Hosp Univ Doctor Negrin, Las Palmas Gran Canaria, Spain
[Illera, O.] Hosp Univ Infanta Sofia, Madrid, Spain
[Moreira, B.] Complejo Hosp Pontevedra, Pontevedra, Spain
[Raya, E.] Hosp Clin Univ San Cecilio, Granada, Spain
[Rodriguez Lopez, M.] Hosp Meixoeiro, Vigo, Spain
[Judez, E.] Hosp Univ Albacete, Albacete, Spain
[Moriano, C.] Hosp Univ Leon, Leon, Spain
[Torrente-Segarra, V.] Hosp Gen Hosp, Barcelona, Spain
[Garcia Magallon, B.] Hosp Univ Miguel Servet, Zaragoza, Spain
[Guillen Astete, C.] Hosp Univ Ramon & Cajal, Madrid, Spain
[Castellvi, I.] Hosp Univ Santa Creu & St Pau, Barcelona, Spain
[Bohorquez, C.] Hosp Univ Principe Asturias, Madrid, Spain
[Belzunegui, J.] Hosp Univ Donostia, Guipuzcoa, Spain
Keywords: 
Issue Date: 1-Jan-2020
Publisher: Clinical & exper rheumatology
Abstract: Objective. Digestive involvement (DI) has been reported in 10-30% of primary Sjogren's syndrome (pSS) patients, and few studies have systematically analysed the prevalence of DI in pSS patients. The aim of this study was to describe DI prevalence in pSS patients from the Sjogrenser Study, and to analyse its clinical associations.Methods. All patients included in the Sjogrenser study, a Spanish multicentre randomised cohort, containing demographic, clinical and histologic data, have been analysed retrospectively. Patients were classified according to the presence of DI (oesophageal, gastric, intestinal, hepatic and pancreatic), and we have performed DI clinical associations, descriptive statistics, Student t or chi(2) test, and uni and multivariate logistic regression.Results. From 437 included patients, 95% were women, with a median age of 58 years, 71 (16.2%) presented DI: 21 (29.5%) chronic atrophic gastritis, 12 (16.9%) oesophageal motility dysfunction, 3 (4.2%) lymphocytic colitis, 18 (25.3%) primary biliary cholangitis, 15 (21.1%) autoimmune hepatitis, 7 (9.8%) pancreatic involvement and 5 (7%) coeliac disease. Half of them developed DI at the same time or after pSS diagnosis. Patients with DI were significantly older at pSS diagnosis (p=0.032), more frequently women (p=0.009), presented more autoimmune hypothyroidism and C3 hypocomplementaemia (p=0.040), and were treated more frequently with glucocorticoids, immunosuppressant and biologic therapies. Patients with pancreatic involvement presented more central nervous system and renal involvement, Raynaud's phenomenon, lymphoma and C3/C4 hypocomplementaemia.Conclusion. DI is frequent in Sjogrenser patients, mainly in the form of autoimmune disorders, and seem to be associated with a more severe phenotype. Our results suggest that DI should be evaluated in pSS patients, especially those with more severe disease.
URI: https://hdl.handle.net/20.500.12530/55991
ISSN: 0392-856X
Appears in Collections:Fundaciones e Institutos de Investigación > FIIB H. U. Infanta Sofía y H. U. Henares > Artículos

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