Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/56118
Title: An Exceptional Case of Light Chain Only Variant of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits Secondary to Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature
Authors: 
Filiation: Servicio de Medicina Interna. Nefrología. Hospital Universitario de Fuenlabrada
Mesh: 
Decs: 
Issue Date: Oct-2022
Publisher: Hindawi Limited
Citation: De La Flor JC, Apaza J, Díaz F, Sandoval E, Linares T, Marschall A, Núñez P, Rivas-Nieto AC, Ruiz E. An Exceptional Case of Light Chain Only Variant of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits Secondary to Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature. Case Rep Nephrol. 2022 Oct 19;2022:9207282. doi: 10.1155/2022/9207282. PMID: 36312462; PMCID: PMC9605840.
Abstract: We present the case of an 86-year-old Caucasian male with an 11-year history of low-grade chronic lymphocytic leukemia (CLL) presenting with nephrotic syndrome (NS). Renal biopsy findings showed a diffuse mesangial and endocapillary proliferative glomerulonephritis (GN) lesion with fine granular deposits, consistent with a rare morphologic variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID)-lambda light chain (LC) only. Monthly combination therapy of rituximab (500 mg/m2 on day 1), fludarabine (30 mg/m2 on days 1-3), and cyclophosphamide (750 mg/m2 on days 1-3) was administered. Five courses of this regimen resulted in hematological remission, as well as a partial renal response with a reduction in the spot urine protein-to-creatinine ratio (UPCR) of 815.3 mg/g (reduction > 50% proteinuria without improvement in kidney function). This condition is a rare morphological variant of PGNMID, poorly described in CLL patients. We review the literature and suggest that this case provides sheds light on the unknown pathophysiological mechanisms of monoclonal immunoglobulins (MIg)-mediated glomerular damage in CLL patients, and may be helpful for the investigation of a more effective treatment.
PMID: 36312462
URI: https://hdl.handle.net/20.500.12530/56118
Rights: info:eu-repo/semantics/openAccess
Atribución-NoComercial-CompartirIgual 3.0 España
ISSN: 2090-665X
Appears in Collections:Hospitales > H. U. de Fuenlabrada > Artículos

Files in This Item:
File Description SizeFormat 
Case Reports Nephrology.pdf1.38 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons