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Title: Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
Filiation: Servicio de Oncología Médica. Hospital Universitario de Fuenlabrada
Issue Date: 1-Nov-2019
Publisher: Springer Science and Business Media LLC
Citation: Bueno MJ, Jimenez-Renard V, Samino S, Capellades J, Junza A, López-Rodríguez ML, Garcia-Carceles J, Lopez-Fabuel I, Bolaños JP, Chandel NS, Yanes O, Colomer R, Quintela-Fandino M. Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells. Nat Commun. 2019 Nov 1;10(1):5011. doi: 10.1038/s41467-019-13028-1. PMID: 31676791; PMCID: PMC6825217.
Abstract: Upregulation of fatty acid synthase (FASN) is a common event in cancer, although its mechanistic and potential therapeutic roles are not completely understood. In this study, we establish a key role of FASN during transformation. FASN is required for eliciting the anaplerotic shift of the Krebs cycle observed in cancer cells. However, its main role is to consume acetyl-CoA, which unlocks isocitrate dehydrogenase (IDH)-dependent reductive carboxylation, producing the reductive power necessary to quench reactive oxygen species (ROS) originated during the switch from two-dimensional (2D) to three-dimensional (3D) growth (a necessary hallmark of cancer). Upregulation of FASN elicits the 2D-to-3D switch; however, FASN's synthetic product palmitate is dispensable for this process since cells satisfy their fatty acid requirements from the media. In vivo, genetic deletion or pharmacologic inhibition of FASN before oncogenic activation prevents tumor development and invasive growth. These results render FASN as a potential target for cancer prevention studies.
PMID: 31676791
Rights: info:eu-repo/semantics/openAccess
Atribución 3.0 España
ISSN: 2041-1723
Appears in Collections:Hospitales > H. U. de Fuenlabrada > Artículos

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