Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12530/56145
Título : Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
Autor : 
Filiación: Servicio de Oncología Médica. Hospital Universitario de Fuenlabrada
Mesh: 
Decs: 
Fecha de publicación : 1-nov-2019
Editorial : Springer Science and Business Media LLC
Citación : Bueno MJ, Jimenez-Renard V, Samino S, Capellades J, Junza A, López-Rodríguez ML, Garcia-Carceles J, Lopez-Fabuel I, Bolaños JP, Chandel NS, Yanes O, Colomer R, Quintela-Fandino M. Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells. Nat Commun. 2019 Nov 1;10(1):5011. doi: 10.1038/s41467-019-13028-1. PMID: 31676791; PMCID: PMC6825217.
Resumen : Upregulation of fatty acid synthase (FASN) is a common event in cancer, although its mechanistic and potential therapeutic roles are not completely understood. In this study, we establish a key role of FASN during transformation. FASN is required for eliciting the anaplerotic shift of the Krebs cycle observed in cancer cells. However, its main role is to consume acetyl-CoA, which unlocks isocitrate dehydrogenase (IDH)-dependent reductive carboxylation, producing the reductive power necessary to quench reactive oxygen species (ROS) originated during the switch from two-dimensional (2D) to three-dimensional (3D) growth (a necessary hallmark of cancer). Upregulation of FASN elicits the 2D-to-3D switch; however, FASN's synthetic product palmitate is dispensable for this process since cells satisfy their fatty acid requirements from the media. In vivo, genetic deletion or pharmacologic inhibition of FASN before oncogenic activation prevents tumor development and invasive growth. These results render FASN as a potential target for cancer prevention studies.
PMID: 31676791
URI : https://hdl.handle.net/20.500.12530/56145
Derechos: info:eu-repo/semantics/openAccess
Atribución 3.0 España
ISSN : 2041-1723
Aparece en las colecciones: Hospitales > H. U. de Fuenlabrada > Artículos

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