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Title: COVID-19: Critical appraisal of the evidence
[Rodriguez, Paz Gonzalez] Ctr Salud Barrio del Pilar, Madrid, Spain
[Agapito, Begona Perez -Moneo] Hosp Univ Infanta Leonor, Madrid, Spain
[Rodriguez, Maria Salome Albi] Hosp Univ 12 Octubre, Madrid, Spain
[Galdeano, Pilar Aizpurua] Ctr Salud Ondarreta, San Sebastian, Guipuzcoa, Spain
[Rodrigo, Maria Aparicio] Ctr Salud Entrevias, Madrid, Spain
[Rodriguez, Maria Mercedes Fernandez] Ctr Salud Potes, Madrid, Spain
[Olcina, Maria Jesus Esparza] Atenc Primaria, Madrid, Spain
[Sangrador, Carlos Ochoa] Complejo Asistencial Zamora, Zamora, Spain
Issue Date: 2-Sep-2021
Publisher: Ediciones doyma s a
Abstract: We present the summary of a critical appraisal document of the available evidence on COVID-19, developed with a clinical practice guide format following GRADE methodology. The document tries to provide answers to a series of structured clinical questions, with an explicit definition of the population, intervention/exposure, comparison and outcome, and a rating of the clinical relevance of the outcome measures. We conducted a systematic review of the literature to answer the questions, grouped into six chapters: epidemiology, clinical practice, diagnosis, treatment, prevention, and vaccination. We assessed the risk of bias of the selected studies with standard instruments (RoB-2, ROBINS-I, QUADAS and Newcastle-Ottawa). We constructed evidence tables and, when necessary and possible, meta-analysis of the of the most relevant outcome measures. We followed the GRADE system to synthesize the evidence, assessing its quality, and, when appropriate, giving recommendations, rated according to the quality of the evidence, the values and preferences, the balance between benefits, risks and costs, equity and feasibility. (C) 2021 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.
ISSN: 1695-4033
Appears in Collections:Centros de Atención Primaria > Artículos

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