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|Title:||Survival Trends in Infants Undergoing Allogeneic Hematopoietic Cell Transplant.|
Cause of Death
Hematopoietic Stem Cell Transplantation
Hepatic Veno-Occlusive Disease
Immunologic Deficiency Syndromes
Lung Diseases, Interstitial
Severe Combined Immunodeficiency
|Abstract:||Studies demonstrating improved survival after allogeneic hematopoietic cell transplant generally exclude infants. To analyze overall survival trends and other outcomes among infants who undergo allogeneic hematopoietic cell transplant. In this cohort study, we used time-trend analysis to evaluate 3 periods: 2000 through 2004, 2005 through 2009, and 2010 through 2014. The study was conducted in a multicenter setting through the Center for International Blood and Marrow Transplant Research, which is made up of a voluntary working group of more than 450 transplant centers worldwide. Two groups of infants aged 1 year or younger in 2 cohorts were included: those with malignant conditions, such as leukemia, and those with nonmalignant disorders, including immunodeficiencies. Data analysis was conducted from July 2017 to December 2018. Allogeneic hematopoietic cell transplant. Survival trends, disease relapse, and toxicity. A total of 2498 infants with a median age of 7 months (range, Survival rates have not improved for infants with malignant diseases over the 15-year study period. Infants with nonmalignant diseases had improved survival rates in the earlier but not the later study period. Higher relapses for the malignant cohort and toxicities for all infants remain significant challenges. Strategies to reduce relapse and toxicity and optimize donor and graft selection may improve outcomes in the future.|
|Appears in Collections:||Fundaciones e Institutos de Investigación > FIB H. Infantil U. Niño Jesús > Artículos|
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