Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/56898
Title: [Multidisciplinary consensus on optimizing the detection of NTRK gene alterations in tumours].
Other Titles: Consenso multidisciplinar para optimizar la determinación de alteraciones del gen NTRK.
Authors: 
Keywords: 
Mesh: 
Issue Date: 10-Jul-2021
Citation: Rev Esp Patol.2021;(54)4:250-262
Abstract: The recent identification of rearrangements of neurotrophic tyrosine receptor kinase (NTRK) genes and the development of specific fusion protein inhibitors, such as larotrectinib and entrectinib, have revolutionized the diagnostic and clinical management of patients presenting with tumours with these alterations. Tumours that harbour NTRK fusions are found in both adults and children and are either rare tumours with common NTRK fusions that may be diagnostic, or more common tumours with rare NTRK fusions. To assess the currently available evidence, 3key Spanish medical societies (the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Pathology (SEAP) and the Spanish Society of Paediatric Haematology and Oncology (SEHOP) have brought together a group of experts to develop a consensus document that includes guidelines on the diagnostic, clinical and therapeutic aspects of NTRK-fusion tumours. It also discusses the challenges related to the routine detection of these genetic alterations in a mostly public health care system.
PMID: 34544555
URI: https://hdl.handle.net/20.500.12530/56898
Appears in Collections:Fundaciones e Institutos de Investigación > FIB H. Infantil U. Niño Jesús > Artículos

Files in This Item:
The file with the full text of this item is not available due to copyright restrictions or because there is no digital version. Authors can contact the head of the repository of their center to incorporate the corresponding file.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.