Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/57238
Title: The Role of Basophil Activation Test in Drug Allergy
Authors: 
Filiation: 
[Fernandez-Santamaria, R.] Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain
[Bogas, G.] Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain
[Salas, M.] Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain
[Laguna, J. J.] Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain
[Fernandez, T. D.] Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain
[Torres, M. J.] Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain
[Mayorga, C.] Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain
[Fernandez-Santamaria, R.] Univ Malaga UMA, Dept Med, Malaga, Spain
[Torres, M. J.] Univ Malaga UMA, Dept Med, Malaga, Spain
[Bogas, G.] Hosp Reg Univ Malaga HRUM, Allergy Unit, Malaga, Spain
[Salas, M.] Hosp Reg Univ Malaga HRUM, Allergy Unit, Malaga, Spain
[Torres, M. J.] Hosp Reg Univ Malaga HRUM, Allergy Unit, Malaga, Spain
[Mayorga, C.] Hosp Reg Univ Malaga HRUM, Allergy Unit, Malaga, Spain
[Laguna, J. J.] Hosp Cruz Roja, Allergy Unit, Madrid, Spain
[Fernandez, T. D.] Univ Malaga, Dept Biol Celular Genet & Fisiol, Malaga, Spain
[Torres, M. J.] Ctr Andaluz Nanomed Biotecnol BIONAND, Nanostructures Diagnosing & Treatment Allerg Dis, Malaga, Spain
[Mayorga, C.] Ctr Andaluz Nanomed Biotecnol BIONAND, Nanostructures Diagnosing & Treatment Allerg Dis, Malaga, Spain
[Mayorga, C.] Hosp Reg Univ Malaga IBIMA, Res Lab, Allergy Res Grp, Malaga 29009, Spain
Keywords: 
Issue Date: 9-Dec-2021
Publisher: Springernature
Abstract: Background Basophil activation test (BAT) is a reliable in vitro test, useful to evaluate immediate drug hypersensitivity reactions (IDHRs). Nevertheless, the immunological mechanisms involved in the basophil degranulation are still not completely understood. This and the lack of standardisation hamper the BAT inclusion in clinical routine. This review tries to summarise the different diagnostic values of BAT according to the drugs involved, focusing on the most frequent drug families. Moreover, different technical aspects that could help improve BAT sensitivity have been analysed. Recent findings In the last years, new potential applications of BAT apart from its direct use in the diagnosis of IDHRs have been proposed. Some of them are the assessment of IgE-mediated mechanism, the study of cross-reactivity between drugs with similar chemical structures to find safe alternatives, or its use as a monitorisation tool in desensitisation procedures. The use of BAT in the diagnosis of IDHRs has been widely investigated for some drug families with promising results. Nevertheless, there are some factors that should be carefully considered to improve BAT sensitivity. Finally, new approaches in which BAT provides a wide range of possibilities have been proposed.
URI: https://hdl.handle.net/20.500.12530/57238
Appears in Collections:Hospitales > H. Central de la Cruz Roja San José y Santa Adela > Artículos

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