Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/57699
Title: Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course.
Authors: 
Cavagna, Lorenzo
Trallero-Araguás, Ernesto
Meloni, Federica
Cavazzana, Ilaria
Rojas-Serrano, Jorge
Feist, Eugen
Zanframundo, Giovanni
Morandi, Valentina
Meyer, Alain
Pereira da Silva, Jose Antonio
Matos Costa, Carlo Jorge
Molberg, Oyvind
Andersson, Helena
Codullo, Veronica
Mosca, Marta
Barsotti, Simone
Neri, Rossella
Scirè, Carlo
Govoni, Marcello
Furini, Federica
Lopez-Longo, Francisco Javier
Martinez-Barrio, Julia
Schneider, Udo
Lorenz, Hanns-Martin
Doria, Andrea
Ghirardello, Anna
Ortego-Centeno, Norberto
Confalonieri, Marco
Tomietto, Paola
Pipitone, Nicolò
Rodriguez Cambron, Ana Belen
Blázquez Cañamero, María Ángeles
Voll, Reinhard Edmund
Wendel, Sarah
Scarpato, Salvatore
Maurier, Francois
Limonta, Massimiliano
Colombelli, Paolo
Giannini, Margherita
Geny, Bernard
Arrigoni, Eugenio
Bravi, Elena
Migliorini, Paola
Mathieu, Alessandro
Piga, Matteo
Drott, Ulrich
Delbrueck, Christiane
Bauhammer, Jutta
Cagnotto, Giovanni
Vancheri, Carlo
Sambataro, Gianluca
De Langhe, Ellen
Sainaghi, Pier Paolo
Monti, Cristina
Gigli Berzolari, Francesca
Romano, Mariaeva
Bonella, Francesco
Specker, Christof
Schwarting, Andreas
Villa Blanco, Ignacio
Selmi, Carlo
Ceribelli, Angela
Nuno, Laura
Mera-Varela, Antonio
Perez Gomez, Nair
Fusaro, Enrico
Parisi, Simone
Sinigaglia, Luigi
Del Papa, Nicoletta
Benucci, Maurizio
Cimmino, Marco Amedeo
Riccieri, Valeria
Conti, Fabrizio
Sebastiani, Gian Domenico
Iuliano, Annamaria
Emmi, Giacomo
Cammelli, Daniele
Sebastiani, Marco
Manfredi, Andreina
Bachiller-Corral, Javier
Sifuentes Giraldo, Walter Alberto
Paolazzi, Giuseppe
Saketkoo, Lesley Ann
Giorgi, Roberto
Salaffi, Fausto
Cifrian, Jose
Caporali, Roberto
Locatelli, Francesco
Marchioni, Enrico
Pesci, Alberto
Dei, Giulia
Pozzi, Maria Rosa
Claudia, Lomater
Distler, Jorg
Knitza, Johannes
Schett, George
Iannone, Florenzo
Fornaro, Marco
Franceschini, Franco
Quartuccio, Luca
Gerli, Roberto
Bartoloni, Elena
Bellando Randone, Silvia
Zampogna, Giuseppe
Gonzalez Perez, Montserrat I
Mejia, Mayra
Vicente, Esther
Triantafyllias, Konstantinos
Lopez-Mejias, Raquel
Matucci-Cerinic, Marco
Selva-O'Callaghan, Albert
Castañeda, Santos
Montecucco, Carlomaurizio
Gonzalez-Gay, Miguel Angel
Keywords: 
Issue Date: 18-Nov-2019
Citation: J Clin Med.2019;(8)11:
Abstract: Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group's cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The "ex-novo" occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies' positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.
PMID: 31752231
URI: https://hdl.handle.net/20.500.12530/57699
Rights: openAccess
ISSN: 2077-0383
Appears in Collections:Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos

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