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dc.contributor.authorPaja, Miguel
dc.contributor.authorZafón, Carles
dc.contributor.authorIglesias, Carmela
dc.contributor.authorUgalde, Aitziber
dc.contributor.authorCameselle-Teijeiro, Jose Manuel
dc.contributor.authorRodríguez-Carnero, Gemma
dc.contributor.authorFernández-Seara, Pilar
dc.contributor.authorAnda, Emma
dc.contributor.authorPovoa, Antónia
dc.contributor.authorQuiceno, Hernán
dc.contributor.authorSánchez-Gómez, Nancy M
dc.contributor.authorGonzález, Clarisa
dc.contributor.authorGarcía-Pascual, Luis
dc.contributor.authorGómez de la Riva, Inés
dc.contributor.authorBlanco, Concha
dc.contributor.authorMeizoso, Telma
dc.contributor.authorRiesco-Eizaguirre, Garcilaso
dc.contributor.authorCapel, Ismael
dc.contributor.authorOrtega, María Victoria
dc.contributor.authorMancha, Isabel
dc.contributor.authorChao, Montserrat
dc.contributor.authorAlcázar, Victoria
dc.contributor.authorRoselló, Esther
dc.contributor.authorMaravall, Javier
dc.contributor.authorLópez-Agulló, Susana
dc.contributor.authorPérez-Lázaro, Antonia
dc.contributor.authorMeseguer, Pascual
dc.contributor.authorSanz, Javier
dc.contributor.authorParicio, Jose J
dc.contributor.authorEcheverría, Saioa
dc.contributor.authorCastaño, Ángel
dc.contributor.authorBella, Rosa M
dc.description.abstractTo determine the rate of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in a multi-institutional series from the Iberian Peninsula and describing this NIFTP cohort. Retrospective study of papillary thyroid carcinoma (PTC) or well-differentiated tumours of uncertain malignant potential (WDT-UMP) diagnosed between 2005 and 2015 and measuring ≥5 mm in adult patients from 17 hospitals. Pathological reports were reviewed to determine the cases that fulfil the original criteria of NIFTP and histology was reassessed. Rates were correlated with the number of PTC and its follicular variant (FVPTC) of each institution. Demographic data, histology, management, and follow-up of the reclassified NIFTP cohort were recorded. A total of 182 cases with NIFTP criteria were identified: 174/3372 PTC (rate: 5.2%; range: 0-12.1%) and 8/19 WDT-UMP (42.1%). NIFTP rate showed linear correlation with total PTC (p: 0.03) and FVPTC (p: 0.007) identified at each centre. Ultrasound findings were non-suspicious in 60.1%. Fine-needle cytology or core biopsy diagnoses were undetermined in 49.7%. Most patients were treated with total thyroidectomy. No case had nodal disease. Among patients with total thyroidectomy, 89.7% had an excellent response evaluated 1 year after surgery. There were no structural persistence or relapses. Five patients showed residual thyroglobulin after 90 months of mean follow-up. NIFTP rate is low but highly variable in neighbouring institutions of the Iberian Peninsula. This study suggests pathologist's interpretation of nuclear alterations as the main cause of these differences. Patients disclosed an excellent outcome, even without using the strictest criteria.
dc.subjectPapillary thyroid carcinoma
dc.subjectRetrospective study
dc.subjectThyroid neoplasm
dc.subject.meshAdenocarcinoma, Follicular
dc.subject.meshFollow-Up Studies
dc.subject.meshNeoplasm Recurrence, Local
dc.subject.meshRetrospective Studies
dc.subject.meshThyroid Neoplasms
dc.titleRate of non-invasive follicular thyroid neoplasms with papillary-like nuclear features depends on pathologist's criteria: a multicentre retrospective Southern European study with prolonged follow-up.
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
Appears in Collections:Hospitales > H. U. Severo Ochoa > Artículos

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