Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFernandez-Cotarelo, Maria-Jose-
dc.contributor.authorNagy-Agren, Stephanie E-
dc.contributor.authorSmolkin, Mark E-
dc.contributor.authorJimenez-Diez-Canseco, Leticia-
dc.contributor.authorPérez Pomata, María Teresa-
dc.contributor.authorShenal, Brian V-
dc.contributor.authorWarren, Cirle A-
dc.identifier.citationJ Gen Intern Med.2019 Aug;(34)8:1392-1393es_ES
dc.description.abstractThe gut microbiota composition changes with aging, contributing to risk for Clostridium difficile infection (CDI), and there is evidence of cognitive impairment due to antibiotic-induced gut dysbiosis. However, there is little data about the relationship between functional or cognitive status and CDI. The objective of this study was to determine the association between CDI and functional and/or cognitive status in older patients. Multisite, collaborative international retrospective case-control study. The study was performed at Salem Veterans Affairs Medical Center (Virginia, US), and Hospital Universitario de Mostoles (Madrid, Spain). Participants: Cases were hospitalized patients >60yo with CDI during 2013-2014. Controls were matched to cases by age, sex, and Charlson comorbidity index score (CCI). Measurements: Pre-hospitalization dwelling, CCI, cognitive conditions, functional status, CDI case definition and severity, length of stay, delirium, discharge disposition, readmissions, in-hospital and late mortality. 106 cases were identified, mean age 76.3, mean CCI 3.67. There was significantly increased baseline functional debility and admission from nursing home (NH) or long term care facility (LTCF) in cases, and significantly increased delirium. Cases with delirium had increased death during admission, and cases with cognitive impairment had increased functional decline or death at discharge, and late mortality. We observed significantly increased functional decline or death at discharge, and discharge to a NH, LTCF or death in cases. The combined length of stay and survival outcome was significantly worse for cases, and late mortality at 90 and 180 days was increased. CDI in older patients is associated with functional decline, cognitive impairment and death (including late mortality). These observations emphasize need to address functional and cognitive issues impacting susceptibility and outcomes of CDI in the older host.es_ES
dc.publisherSpringer Science and Business Media LLCes_ES
dc.subjectClostridium difficile infectiones_ES
dc.subjectcognitive impairmentes_ES
dc.subjectfunctional debilityes_ES
dc.subjectgut microbiotaes_ES
dc.subject.meshAged, 80 and overes_ES
dc.subject.meshCase-Control Studieses_ES
dc.subject.meshClostridium Infectionses_ES
dc.subject.meshCognitive Dysfunctiones_ES
dc.subject.meshRetrospective Studieses_ES
dc.titleFunctional and Cognitive Status in Clostridium difficile Infection in the Hospitalized Elderly: a Retrospective Study of Two Siteses_ES
dc.identifier.journalJournal of general internal medicinees_ES
dc.identifier.journalabbreviationJ Gen Intern Medes_ES
dc.contributor.authoraffiliationHospital Universitario de Mostoleses_ES
dc.contributor.authoraffiliationUniversidad Rey Juan Carloses_ES
Appears in Collections:Hospitales > H. U. de Móstoles > Artículos

Files in This Item:
File Description SizeFormat 
fernandez_2019-Functional.pdf674.11 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons